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Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing

The proteostasis network has evolved to support protein folding under normal conditions and to expand this capacity in response to proteotoxic stresses. Nevertheless, many pathogenic states are associated with protein misfolding, revealing in vivo limitations on quality control mechanisms. One contr...

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Detalles Bibliográficos
Autores principales: Klaips, Courtney L, Hochstrasser, Megan L, Langlois, Christine R, Serio, Tricia R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270096/
https://www.ncbi.nlm.nih.gov/pubmed/25490068
http://dx.doi.org/10.7554/eLife.04288