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Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission

Plasmodium vivax relapse infections occur following activation of latent liver-stages parasites (hypnozoites) causing new blood-stage infections weeks to months after the initial infection. We develop a within-host mathematical model of liver-stage hypnozoites, and validate it against data from trop...

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Detalles Bibliográficos
Autores principales: White, Michael T, Karl, Stephan, Battle, Katherine E, Hay, Simon I, Mueller, Ivo, Ghani, Azra C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270097/
https://www.ncbi.nlm.nih.gov/pubmed/25406065
http://dx.doi.org/10.7554/eLife.04692