Translocation between PI(4,5)P(2)-poor and PI(4,5)P(2)-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

The Orai1-STIM1 current undergoes slow Ca(2+)-dependent inactivation (SCDI) mediated by binding of SARAF to STIM1. Here, we report the use of SCDI by SARAF as a probe of the conformation and microdomain localization of the Orai1-STIM1 complex. We find that interaction of STIM1 with Orai1 C terminus...

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Detalles Bibliográficos
Autores principales: Maléth, Jozsef, Choi, Seok, Muallem, Shmuel, Ahuja, Malini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270102/
https://www.ncbi.nlm.nih.gov/pubmed/25517631
http://dx.doi.org/10.1038/ncomms6843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270102/
https://www.ncbi.nlm.nih.gov/pubmed/25517631
http://dx.doi.org/10.1038/ncomms6843

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