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Mitosis, double strand break repair, and telomeres: A view from the end

Double strand break (DSB) repair is suppressed during mitosis because RNF8 and downstream DNA damage response (DDR) factors, including 53BP1, do not localize to mitotic chromatin. Discovery of the mitotic kinase-dependent mechanism that inhibits DSB repair during cell division was recently reported....

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Detalles Bibliográficos
Autor principal: Cesare, Anthony J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY Periodicals, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270212/
https://www.ncbi.nlm.nih.gov/pubmed/25171524
http://dx.doi.org/10.1002/bies.201400104