Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin‐induced cardiomyopathy in mice

A metabolizing enzyme arginase can decrease nitric oxide (NO) production by competing with NO synthase for arginine as a substrate, but its pathophysiological role in heart failure remains unknown. We aimed to investigate the effect of pharmacological inhibition of arginase on left ventricular funct...

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Detalles Bibliográficos
Autores principales: Toya, Takumi, Hakuno, Daihiko, Shiraishi, Yasunaga, Kujiraoka, Takehiko, Adachi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270236/
https://www.ncbi.nlm.nih.gov/pubmed/25263201
http://dx.doi.org/10.14814/phy2.12130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270236/
https://www.ncbi.nlm.nih.gov/pubmed/25263201
http://dx.doi.org/10.14814/phy2.12130

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