Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution

It has been suggested that HIV-1 has evolved its set-point virus load to be optimized for transmission. Previous epidemiological models and studies into the heritability of set-point virus load confirm that this mode of adaptation within the human population is feasible. However, during the many cyc...

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Detalles Bibliográficos
Autores principales: van Dorp, Christiaan H., van Boven, Michiel, de Boer, Rob J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270429/
https://www.ncbi.nlm.nih.gov/pubmed/25522184
http://dx.doi.org/10.1371/journal.pcbi.1003899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270429/
https://www.ncbi.nlm.nih.gov/pubmed/25522184
http://dx.doi.org/10.1371/journal.pcbi.1003899

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