Notch Signaling Mediates the Age-Associated Decrease in Adhesion of Germline Stem Cells to the Niche

Stem cells have an innate ability to occupy their stem cell niche, which in turn, is optimized to house stem cells. Organ aging is associated with reduced stem cell occupancy in the niche, but the mechanisms involved are poorly understood. Here, we report that Notch signaling is increased with age i...

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Detalles Bibliográficos
Autores principales: Tseng, Chen-Yuan, Kao, Shih-Han, Wan, Chih-Ling, Cho, Yueh, Tung, Shu-Yun, Hsu, Hwei-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270478/
https://www.ncbi.nlm.nih.gov/pubmed/25521289
http://dx.doi.org/10.1371/journal.pgen.1004888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270478/
https://www.ncbi.nlm.nih.gov/pubmed/25521289
http://dx.doi.org/10.1371/journal.pgen.1004888

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