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Notch Signaling Mediates the Age-Associated Decrease in Adhesion of Germline Stem Cells to the Niche
Stem cells have an innate ability to occupy their stem cell niche, which in turn, is optimized to house stem cells. Organ aging is associated with reduced stem cell occupancy in the niche, but the mechanisms involved are poorly understood. Here, we report that Notch signaling is increased with age i...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270478/ https://www.ncbi.nlm.nih.gov/pubmed/25521289 http://dx.doi.org/10.1371/journal.pgen.1004888 |