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Membrane Morphology Is Actively Transformed by Covalent Binding of the Protein Atg8 to PE-Lipids
Autophagy is a cellular degradation pathway involving the shape transformation of lipid bilayers. During the onset of autophagy, the water-soluble protein Atg8 binds covalently to phosphatdylethanolamines (PEs) in the membrane in an ubiquitin-like reaction coupled to ATP hydrolysis. We reconstituted...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270758/ https://www.ncbi.nlm.nih.gov/pubmed/25522362 http://dx.doi.org/10.1371/journal.pone.0115357 |