The TCR’s sensitivity to self-peptide–MHC dictates the ability of naïve CD8(+) T cells to respond to foreign antigens

The strength of self-peptide–major histocompatibility complex (MHC) recognition dictates naïve CD8(+) T cell homeostasis, but its effect on foreign antigen reactivity is controversial. As CD5 expression correlates with self-recognition, we studied CD5(lo) and CD5(hi) naïve CD8(+) T cells. Gene expre...

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Detalles Bibliográficos
Autores principales: Fulton, Ross B., Hamilton, Sara E., Xing, Yan, Best, J. Adam, Goldrath, Ananda W., Hogquist, Kristin A., Jameson, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270846/
https://www.ncbi.nlm.nih.gov/pubmed/25419629
http://dx.doi.org/10.1038/ni.3043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270846/
https://www.ncbi.nlm.nih.gov/pubmed/25419629
http://dx.doi.org/10.1038/ni.3043

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