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The TCR’s sensitivity to self-peptide–MHC dictates the ability of naïve CD8(+) T cells to respond to foreign antigens
The strength of self-peptide–major histocompatibility complex (MHC) recognition dictates naïve CD8(+) T cell homeostasis, but its effect on foreign antigen reactivity is controversial. As CD5 expression correlates with self-recognition, we studied CD5(lo) and CD5(hi) naïve CD8(+) T cells. Gene expre...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270846/ https://www.ncbi.nlm.nih.gov/pubmed/25419629 http://dx.doi.org/10.1038/ni.3043 |