In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

Chromosomal rearrangements play a central role in the pathogenesis of human cancers and often result in the expression of therapeutically actionable gene fusions(1). A recently discovered example is a fusion between the Echinoderm Microtubule-associated Protein-like 4 (EML4) and the Anaplastic Lymph...

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Detalles Bibliográficos
Autores principales: Maddalo, Danilo, Manchado, Eusebio, Concepcion, Carla P., Bonetti, Ciro, Vidigal, Joana A., Han, Yoon-Chi, Ogrodowski, Paul, Crippa, Alessandra, Rekhtman, Natasha, de Stanchina, Elisa, Lowe, Scott W., Ventura, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270925/
https://www.ncbi.nlm.nih.gov/pubmed/25337876
http://dx.doi.org/10.1038/nature13902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270925/
https://www.ncbi.nlm.nih.gov/pubmed/25337876
http://dx.doi.org/10.1038/nature13902

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