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In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Chromosomal rearrangements play a central role in the pathogenesis of human cancers and often result in the expression of therapeutically actionable gene fusions(1). A recently discovered example is a fusion between the Echinoderm Microtubule-associated Protein-like 4 (EML4) and the Anaplastic Lymph...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270925/ https://www.ncbi.nlm.nih.gov/pubmed/25337876 http://dx.doi.org/10.1038/nature13902 |