GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors

A fundamental challenge in treating disease is identifying molecular states that affect cellular responses to drugs. Here, we focus on GSK-3, a key regulator for many of the hallmark behaviors of cancer cells. We alter GSK-3 activity in colon epithelial cells to test its role in modulating drug resp...

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Detalles Bibliográficos
Autores principales: Thorne, Curtis A., Wichaidit, Chonlarat, Coster, Adam D., Posner, Bruce A., Wu, Lani F., Altschuler, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270937/
https://www.ncbi.nlm.nih.gov/pubmed/25402767
http://dx.doi.org/10.1038/nchembio.1690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270937/
https://www.ncbi.nlm.nih.gov/pubmed/25402767
http://dx.doi.org/10.1038/nchembio.1690

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