Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity

BACKGROUND: Mounting evidence points to individual contributions of tumour necrosis factor-alpha (TNF) and the c-Jun N-terminal kinase (JNK) pathway to the induction and maintenance of various pain states. Here we explore the role of spinal TNF and JNK in carrageenan-induced hypersensitivity. As lin...

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Detalles Bibliográficos
Autores principales: Bas, DB, Abdelmoaty, S, Sandor, K, Codeluppi, S, Fitzsimmons, B, Steinauer, J, Hua, XY, Yaksh, TL, Svensson, CI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270961/
https://www.ncbi.nlm.nih.gov/pubmed/24942612
http://dx.doi.org/10.1002/ejp.544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270961/
https://www.ncbi.nlm.nih.gov/pubmed/24942612
http://dx.doi.org/10.1002/ejp.544

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