Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome

IL-1α and β are key players in the innate immune system. The secretion of these cytokines by dendritic cells (DC) is integral to the development of proinflammatory responses. These cytokines are not secreted via the classical secretory pathway. Instead, 2 independent processes are required; an initi...

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Detalles Bibliográficos
Autores principales: Ainscough, Joseph S., Frank Gerberick, G., Zahedi-Nejad, Maryam, Lopez-Castejon, Gloria, Brough, David, Kimber, Ian, Dearman, Rebecca J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271241/
https://www.ncbi.nlm.nih.gov/pubmed/25371210
http://dx.doi.org/10.1074/jbc.M114.595686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271241/
https://www.ncbi.nlm.nih.gov/pubmed/25371210
http://dx.doi.org/10.1074/jbc.M114.595686

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