Differential Effects of a Mutation on the Normal and Promiscuous Activities of Orthologs: Implications for Natural and Directed Evolution

Neutral drift occurring over millions or billions of years results in substantial sequence divergence among enzymes that catalyze the same reaction. Although natural selection maintains the primary activity of orthologous enzymes, there is, by definition, no selective pressure to maintain physiologi...

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Detalles Bibliográficos
Autores principales: Khanal, Akhil, Yu McLoughlin, Sean, Kershner, Jamie P., Copley, Shelley D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271523/
https://www.ncbi.nlm.nih.gov/pubmed/25246702
http://dx.doi.org/10.1093/molbev/msu271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271523/
https://www.ncbi.nlm.nih.gov/pubmed/25246702
http://dx.doi.org/10.1093/molbev/msu271

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