Toward More Accurate Ancestral Protein Genotype–Phenotype Reconstructions with the Use of Species Tree-Aware Gene Trees

The resurrection of ancestral proteins provides direct insight into how natural selection has shaped proteins found in nature. By tracing substitutions along a gene phylogeny, ancestral proteins can be reconstructed in silico and subsequently synthesized in vitro. This elegant strategy reveals the c...

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Detalles Bibliográficos
Autores principales: Groussin, Mathieu, Hobbs, Joanne K., Szöllősi, Gergely J., Gribaldo, Simonetta, Arcus, Vickery L., Gouy, Manolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Fast Track
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271536/
https://www.ncbi.nlm.nih.gov/pubmed/25371435
http://dx.doi.org/10.1093/molbev/msu305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271536/
https://www.ncbi.nlm.nih.gov/pubmed/25371435
http://dx.doi.org/10.1093/molbev/msu305

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