Cargando…

The Synergistic Repressive Effect of NF-κB and JNK Inhibitor on the Clonogenic Capacity of Jurkat Leukemia Cells

Deregulation of Nuclear Transcription Factor-κB (NF-κB) and Jun N-terminal kinase (JNK) signaling is commonly detected in leukemia, suggesting an important role for these two signaling pathways in the pathogenesis of leukemia. In this study, using Jurkat cells, an acute T-lymphoblastic leukemia (T-A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xinli, Zhang, Jun, Li, Jing, Volk, Andrew, Breslin, Peter, Zhang, Jiwang, Zhang, Zhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272284/ https://www.ncbi.nlm.nih.gov/pubmed/25526629 http://dx.doi.org/10.1371/journal.pone.0115490

Ejemplares similares

Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML
por: Volk, Andrew, et al.
Publicado: (2014)

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling
por: Li, Jing, et al.
Publicado: (2016)

XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells
por: Moreno-Martínez, Daniel, et al.
Publicado: (2014)

Differential cytokine regulation by NF-κB and AP-1 in Jurkat T-cells
por: Khalaf, Hazem, et al.
Publicado: (2010)

TLRs, NF-κB, JNK, and Liver Regeneration
por: Iimuro, Yuji, et al.
Publicado: (2010)

Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice
por: Zhang, Lei, et al.
Publicado: (2022)

Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis
por: Wang, Jing, et al.
Publicado: (2011)

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
por: Maeda, Shin
Publicado: (2010)

Targeting Epigenetic Modifiers Can Reduce the Clonogenic Capacities of Sézary Cells
por: Chebly, Alain, et al.
Publicado: (2021)

Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways
por: Alhosin, Mahmoud, et al.
Publicado: (2020)

Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082
por: Zhang, Lingyu, et al.
Publicado: (2019)

Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling
por: Su, Zhipeng, et al.
Publicado: (2021)

Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity
por: Gopalakrishnapillai, Anilkumar, et al.
Publicado: (2014)

Sunitinib effectively reduces clonogenic acute myeloid leukemia cells in vitro
por: Ahmed, Farid, et al.
Publicado: (2014)

Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells
por: Cornet-Masana, Josep Maria, et al.
Publicado: (2016)

Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity
por: Janeckova, Lucie, et al.
Publicado: (2016)

Clonogenic Assay of Gastric Adenocarcinoma Stem Cells: Clonogenic Assay, Stomach Cancer
por: Kim, Hoon Kyo, et al.
Publicado: (1987)

Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma
por: Daenthanasanmak, Anusara, et al.
Publicado: (2022)

TWIST-1 promotes cell growth, drug resistance and progenitor clonogenic capacities in myeloid leukemia and is a novel poor prognostic factor in acute myeloid leukemia
por: Wang, Nan, et al.
Publicado: (2015)

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
por: Zhang, Kun, et al.
Publicado: (2023)

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway
por: Smith, Emma M., et al.
Publicado: (2013)

Melibiosamine, a novel oligosaccharide, suppresses mitogen-induced IL-2 production via inactivation of NFAT and NFκB in Jurkat cells
por: Fujita, Kazuki, et al.
Publicado: (2019)

CDK4 regulation by TNFR1 and JNK is required for NF-κB–mediated epidermal growth control
por: Zhang, Jennifer Y., et al.
Publicado: (2005)

NKILA represses nasopharyngeal carcinoma carcinogenesis and metastasis by NF-κB pathway inhibition
por: Zhang, Wei, et al.
Publicado: (2019)

Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility
por: Liu, Yehua, et al.
Publicado: (2015)

Mitofusin-2 mediates doxorubicin sensitivity and acute resistance in Jurkat leukemia cells
por: Decker, Carl W., et al.
Publicado: (2020)

Overexpression of MiR-506 in Jurkat (Acute T Cell Leukemia) Cell Line
por: Rostami Yasuj, Shaghayegh, et al.
Publicado: (2020)

Neurotropin Suppresses Inflammatory Cytokine Expression and Cell Death through Suppression of NF-κB and JNK in Hepatocytes
por: Zhang, Bi, et al.
Publicado: (2014)

JNK‐IN‐8 treatment improves ARDS‐induced cognitive impairment by inhibiting JNK/NF‐κB‐mediated NLRP3 inflammasome
por: Shi, Yunchao, et al.
Publicado: (2023)

Puerarin Increases Survival and Protects Against Organ Injury by Suppressing NF-κB/JNK Signaling in Experimental Sepsis
por: Wang, Lei, et al.
Publicado: (2020)

Prolactin receptor signaling induces acquisition of chemoresistance and reduces clonogenicity in acute myeloid leukemia
por: Cuesta-Casanovas, Laia, et al.
Publicado: (2023)

NF-κB Repression by PIAS3 Mediated RelA SUMOylation
por: Liu, Yuangang, et al.
Publicado: (2012)

Foxp3 Interacts with c-Rel to Mediate NF-κB Repression
por: Loizou, Louiza, et al.
Publicado: (2011)

Synergistic activity of sorafenib and betulinic acid against clonogenic activity of non‐small cell lung cancer cells
por: Kutkowska, Justyna, et al.
Publicado: (2017)

Apoptosis-inducing effects of jujube (Zǎo) seed extracts on human Jurkat leukemia T cells
por: Taechakulwanijya, Natthanan, et al.
Publicado: (2016)

Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell
por: Wu, Ran, et al.
Publicado: (2018)

Methyl-Thiol-Bridged Oxadiazole and Triazole Heterocycles as Inhibitors of NF-κB in Chronic Myelogenous Leukemia Cells
por: Basappa, Basappa, et al.
Publicado: (2023)

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
por: Zhang, Lei, et al.
Publicado: (2020)

An artefact in clonogenic assays of bleomycin cytotoxicity.
por: Twentyman, P. R.
Publicado: (1977)

Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity
por: Howell, Sacha J, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_nvlb08thkjos2fqopird0hcemd