Evaluation of Disulfide Bond Position to Enhance the Thermal Stability of a Highly Stable Single Domain Antibody

Single domain antibodies are the small recombinant variable domains derived from camelid heavy-chain-only antibodies. They are renowned for their stability, in large part due to their ability to refold following thermal or chemical denaturation. In addition to refolding after heat denaturation, A3,...

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Detalles Bibliográficos
Autores principales: Zabetakis, Dan, Olson, Mark A., Anderson, George P., Legler, Patricia M., Goldman, Ellen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272287/
https://www.ncbi.nlm.nih.gov/pubmed/25526640
http://dx.doi.org/10.1371/journal.pone.0115405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272287/
https://www.ncbi.nlm.nih.gov/pubmed/25526640
http://dx.doi.org/10.1371/journal.pone.0115405

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