Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes

BACKGROUND: The extent of intratumoral mutational heterogeneity remains unclear in gliomas, the most common primary brain tumors, especially with respect to point mutation. To address this, we applied single molecule molecular inversion probes targeting 33 cancer genes to assay both point mutations...

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Detalles Bibliográficos
Autores principales: Kumar, Akash, Boyle, Evan A, Tokita, Mari, Mikheev, Andrei M, Sanger, Michelle C, Girard, Emily, Silber, John R, Gonzalez-Cuyar, Luis F, Hiatt, Joseph B, Adey, Andrew, Lee, Choli, Kitzman, Jacob O, Born, Donald E, Silbergeld, Daniel L, Olson, James M, Rostomily, Robert C, Shendure, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272528/
https://www.ncbi.nlm.nih.gov/pubmed/25608559
http://dx.doi.org/10.1186/s13059-014-0530-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272528/
https://www.ncbi.nlm.nih.gov/pubmed/25608559
http://dx.doi.org/10.1186/s13059-014-0530-z

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