6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells

BACKGROUND: The antimetabolite 6-thioguanine (6-TG) has been used to treat both human and canine lymphoid malignancies. 6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell line, causing downregulation of DNA methyltransferase 1 (DNMT1) through ubiquitin-...

Descripción completa

Detalles Bibliográficos
Autores principales: Flesner, Brian K, Kumar, Senthil R, Bryan, Jeffrey N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272768/
https://www.ncbi.nlm.nih.gov/pubmed/25480665
http://dx.doi.org/10.1186/s12917-014-0290-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272768/
https://www.ncbi.nlm.nih.gov/pubmed/25480665
http://dx.doi.org/10.1186/s12917-014-0290-8

Ejemplares similares