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6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells

BACKGROUND: The antimetabolite 6-thioguanine (6-TG) has been used to treat both human and canine lymphoid malignancies. 6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell line, causing downregulation of DNA methyltransferase 1 (DNMT1) through ubiquitin-...

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Detalles Bibliográficos
Autores principales:	Flesner, Brian K, Kumar, Senthil R, Bryan, Jeffrey N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272768/ https://www.ncbi.nlm.nih.gov/pubmed/25480665 http://dx.doi.org/10.1186/s12917-014-0290-8

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