Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family

BACKGROUND: H2AX is phosphorylated (γH2AX) by members of the phosphatidylinositol 3-kinase (PI3K) family, including Ataxia telangiectasia-mutated (ATM), ATM- and Rad3-related (ATR) and DNA-PK in response to DNA damage. Our study shows that gossypol acetic acid (GAA) alone can induce γH2AX in Human m...

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Detalles Bibliográficos
Autores principales: Guo, Zhong, Zhao, Jin, Song, Lei, Ma, Jian-Xiu, Wang, Chen-Jing, Pei, Shu-Yan, Jiang, Chao, Li, Shang-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272777/
https://www.ncbi.nlm.nih.gov/pubmed/25530717
http://dx.doi.org/10.1186/s12935-014-0141-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272777/
https://www.ncbi.nlm.nih.gov/pubmed/25530717
http://dx.doi.org/10.1186/s12935-014-0141-5

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