The structure function of the death domain of human IRAK-M

BACKGROUND: IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocytes/macrophages and lung epithelial cells. Lack of IRAK-M in mice greatly improv...

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Detalles Bibliográficos
Autores principales: Du, Jiangfeng, Nicolaes, Gerry AF, Kruijswijk, Danielle, Versloot, Miranda, van der Poll, Tom, van ’t Veer, Cornelis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273448/
https://www.ncbi.nlm.nih.gov/pubmed/25481771
http://dx.doi.org/10.1186/s12964-014-0077-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273448/
https://www.ncbi.nlm.nih.gov/pubmed/25481771
http://dx.doi.org/10.1186/s12964-014-0077-3

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