Bypassing Fluoroquinolone Resistance with Quinazolinediones: Studies of Drug–Gyrase–DNA Complexes Having Implications for Drug Design

[Image: see text] Widespread fluoroquinolone resistance has drawn attention to quinazolinediones (diones), fluoroquinolone-like topoisomerase poisons that are unaffected by common quinolone-resistance mutations. To better understand differences between quinolones and diones, we examined their impact...

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Detalles Bibliográficos
Autores principales: Drlica, Karl, Mustaev, Arkady, Towle, Tyrell R., Luan, Gan, Kerns, Robert J., Berger, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273985/
https://www.ncbi.nlm.nih.gov/pubmed/25310082
http://dx.doi.org/10.1021/cb500629k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273985/
https://www.ncbi.nlm.nih.gov/pubmed/25310082
http://dx.doi.org/10.1021/cb500629k

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