Recoding Aminoacyl-tRNA Synthetases for Synthetic Biology by Rational Protein-RNA Engineering

[Image: see text] We have taken a rational approach to redesigning the amino acid binding and aminoacyl–tRNA pairing specificities of bacterial glutaminyl–tRNA synthetase. The four-stage engineering incorporates generalizable design principles and improves the pairing efficiency of noncognate glutam...

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Detalles Bibliográficos
Autores principales: Hadd, Andrew, Perona, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273986/
https://www.ncbi.nlm.nih.gov/pubmed/25310879
http://dx.doi.org/10.1021/cb5006596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273986/
https://www.ncbi.nlm.nih.gov/pubmed/25310879
http://dx.doi.org/10.1021/cb5006596

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