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Olmesartan Decreased Levels of IL-1β and TNF-α, Down-Regulated MMP-2, MMP-9, COX-2, RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model
Methotrexate (MTX) is a pro-oxidant compound that depletes dihydrofolate pools and is widely used in the treatment of leukaemia and other malignancies. The efficacy of methotrexate is often limited by mucositis and intestinal injury, which are major causes of morbidity in children and adults. The ai...
Autores principales: | de Araújo Júnior, Raimundo Fernandes, da Silva Reinaldo, Maria Patrícia Oliveira, Brito, Gerly Anne de Castro, Cavalcanti, Pedro de França, Freire, Marco Aurélio de Moura, de Medeiros, Caroline Addison Xavier, de Araújo, Aurigena Antunes |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273993/ https://www.ncbi.nlm.nih.gov/pubmed/25531650 http://dx.doi.org/10.1371/journal.pone.0114923 |
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