Deficiency in Either 4E-BP1 or 4E-BP2 Augments Innate Antiviral Immune Responses

Genetic deletion of both 4E-BP1 and 4E-BP2 was found to protect cells against viral infections. Here we demonstrate that the individual loss of either 4E-BP1 or 4E-BP2 in mouse embryonic fibroblasts (MEFs) is sufficient to confer viral resistance. shRNA-mediated silencing of 4E-BP1 or 4E-BP2 renders...

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Detalles Bibliográficos
Autores principales: Nehdi, Atef, Sean, Polen, Linares, Izzar, Colina, Rodney, Jaramillo, Maritza, Alain, Tommy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273997/
https://www.ncbi.nlm.nih.gov/pubmed/25531441
http://dx.doi.org/10.1371/journal.pone.0114854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273997/
https://www.ncbi.nlm.nih.gov/pubmed/25531441
http://dx.doi.org/10.1371/journal.pone.0114854

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