Cargando…

Deficiency in Either 4E-BP1 or 4E-BP2 Augments Innate Antiviral Immune Responses

Genetic deletion of both 4E-BP1 and 4E-BP2 was found to protect cells against viral infections. Here we demonstrate that the individual loss of either 4E-BP1 or 4E-BP2 in mouse embryonic fibroblasts (MEFs) is sufficient to confer viral resistance. shRNA-mediated silencing of 4E-BP1 or 4E-BP2 renders...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nehdi, Atef, Sean, Polen, Linares, Izzar, Colina, Rodney, Jaramillo, Maritza, Alain, Tommy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273997/ https://www.ncbi.nlm.nih.gov/pubmed/25531441 http://dx.doi.org/10.1371/journal.pone.0114854

Ejemplares similares

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio
por: Alain, Tommy, et al.
Publicado: (2012)

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis
por: Zakaria, Chadi, et al.
Publicado: (2018)

4E-BP restrains eIF4E phosphorylation
por: Müller, David, et al.
Publicado: (2013)

The expression and significance of p4E‐BP1/4E‐BP1 in prostate cancer
por: Wang, Kai‐yun, et al.
Publicado: (2022)

4E-BP1 as an oncotarget
por: She, Qing-Bai
Publicado: (2015)

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia
por: Le Bacquer, Olivier, et al.
Publicado: (2019)

Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart
por: Santalla, Manuela, et al.
Publicado: (2022)

Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma
por: Li, Feng, et al.
Publicado: (2018)

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
por: Tsukumo, Yoshinori, et al.
Publicado: (2016)

E4BP4 Coordinates Circadian Control of Cognition in Delirium
por: Chen, Min, et al.
Publicado: (2022)

Regulation of 4E-BP1 activity in the mammalian oocyte
por: Jansova, Denisa, et al.
Publicado: (2017)

Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice
por: Cao, Simon, et al.
Publicado: (2023)

The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS
por: Gosselin, Pauline, et al.
Publicado: (2011)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation
por: Castelli, Lydia M., et al.
Publicado: (2015)

Multi-Functional Regulation of 4E-BP Gene Expression by the Ccr4-Not Complex
por: Okada, Hirokazu, et al.
Publicado: (2015)

Circadian-Regulated Cardiac Metabolism Involves Transcription Factor E4BP4
por: Rabinovich-Nikitin, Inna, et al.
Publicado: (2023)

Dendritic eIF4E-binding Protein 1 (eIF4E-BP1) mRNA Is Upregulated by Neuronal Activation
por: Moon, Il Soo, et al.
Publicado: (2012)

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
por: Tain, Luke S, et al.
Publicado: (2009)

Obesity is associated with higher 4E-BP1 expression in endometrial cancer
por: Libby, Emily Falk, et al.
Publicado: (2014)

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo
por: Kamizono, Shintaro, et al.
Publicado: (2009)

The Transcription Factor E4BP4 Is Not Required for Extramedullary Pathways of NK Cell Development
por: Crotta, Stefania, et al.
Publicado: (2014)

Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology
por: Mia, Sobuj, et al.
Publicado: (2023)

Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive
por: Laurent, Sébastien, et al.
Publicado: (2014)

TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals
por: Jin, Hua, et al.
Publicado: (2020)

Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice
por: Sun, Rui, et al.
Publicado: (2023)

Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
por: Sun, Rui, et al.
Publicado: (2019)

The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction
por: Miller, William P., et al.
Publicado: (2016)

Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma
por: Jacobson, B A, et al.
Publicado: (2009)

Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1
por: Grosso, Stefano, et al.
Publicado: (2011)

A novel E4BP4 element drives circadian expression of mPeriod2
por: Ohno, Tomoya, et al.
Publicado: (2007)

New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress
por: Ayuso, María I., et al.
Publicado: (2010)

Dissociation of eIF4E-Binding Protein 2 (4E-BP2) from eIF4E Independent of Thr(37)/Thr(46) Phosphorylation in the Ischemic Stress Response
por: Ayuso, María I., et al.
Publicado: (2015)

4E-BP is a target of the GCN2–ATF4 pathway during Drosophila development and aging
por: Kang, Min-Ji, et al.
Publicado: (2017)

E4BP4 promotes thyroid cancer proliferation by modulating iron homeostasis through repression of hepcidin
por: Zhou, Qinyi, et al.
Publicado: (2018)

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
por: Tang, Patrick Ming-Kuen, et al.
Publicado: (2017)

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
por: Chao, Suzan K., et al.
Publicado: (2011)

PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1
por: Goo, Chong Kiat, et al.
Publicado: (2012)

Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery
por: Mahoney, Rebekah Elizabeth, et al.
Publicado: (2016)

Multifunnel Energy Landscapes for Phosphorylated Translation Repressor 4E-BP2 and Its Mutants
por: Kang, Wei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gag57d7p9evcb4nkh4qsi2lr3q