Evaluation of the “Steal” Phenomenon on the Efficacy of Hypoxia Activated Prodrug TH-302 in Pancreatic Cancer

Pancreatic ductal adenocarcinomas are desmoplastic and hypoxic, both of which are associated with poor prognosis. Hypoxia-activated prodrugs (HAPs) are specifically activated in hypoxic environments to release cytotoxic or cytostatic effectors. TH-302 is a HAP that is currently being evaluated in a...

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Detalles Bibliográficos
Autores principales: Bailey, Kate M., Cornnell, Heather H., Ibrahim-Hashim, Arig, Wojtkowiak, Jonathan W., Hart, Charles P., Zhang, Xiaomeng, Leos, Rafael, Martinez, Gary V., Baker, Amanda F., Gillies, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273999/
https://www.ncbi.nlm.nih.gov/pubmed/25532146
http://dx.doi.org/10.1371/journal.pone.0113586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273999/
https://www.ncbi.nlm.nih.gov/pubmed/25532146
http://dx.doi.org/10.1371/journal.pone.0113586

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