Impact of crystal polymorphism on the systemic bioavailability of rifaximin, an antibiotic acting locally in the gastrointestinal tract, in healthy volunteers

BACKGROUND: Rifaximin is an antibiotic, acting locally in the gastrointestinal tract, which may exist in different crystal as well as amorphous forms. The current marketed rifaximin formulation contains polymorph alpha, the systemic bioavailability of which is very limited. This study compared the p...

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Detalles Bibliográficos
Autores principales: Blandizzi, Corrado, Viscomi, Giuseppe Claudio, Scarpignato, Carmelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274041/
https://www.ncbi.nlm.nih.gov/pubmed/25565769
http://dx.doi.org/10.2147/DDDT.S72572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274041/
https://www.ncbi.nlm.nih.gov/pubmed/25565769
http://dx.doi.org/10.2147/DDDT.S72572

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