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mTORC2 Is Required for Rit-Mediated Oxidative Stress Resistance
Rit, a member of the Ras family of GTPases, has been shown to promote cell survival in response to oxidative stress, in part by directing an evolutionarily conserved p38 MAPK-Akt survival cascade. Aberrant Rit signaling has recently been implicated as a driver mutation in human cancer, adding import...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274107/ https://www.ncbi.nlm.nih.gov/pubmed/25531880 http://dx.doi.org/10.1371/journal.pone.0115602 |