Asymmetric parental genome engineering by Cas9 during mouse meiotic exit

Mammalian genomes can be edited by injecting pronuclear embryos with Cas9 cRNA and guide RNA (gRNA) but it is unknown whether editing can also occur during the onset of embryonic development, prior to pronuclear embryogenesis. We here report Cas9-mediated editing during sperm-induced meiotic exit an...

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Detalles Bibliográficos
Autores principales: Suzuki, Toru, Asami, Maki, Perry, Anthony C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274505/
https://www.ncbi.nlm.nih.gov/pubmed/25532495
http://dx.doi.org/10.1038/srep07621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274505/
https://www.ncbi.nlm.nih.gov/pubmed/25532495
http://dx.doi.org/10.1038/srep07621

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