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Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate

As the only cells capable of efficiently resorbing bone, osteoclasts are central mediators of both normal bone remodeling and pathologies associates with excessive bone resorption. However, despite the clear evidence of interplay between osteoclasts and the bone surface in vivo, the role of the bone...

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Detalles Bibliográficos
Autores principales: Purdue, P. Edward, Crotti, Tania N., Shen, Zhenxin, Swantek, Jennifer, Li, Jun, Hill, Jonathan, Hanidu, Adedayo, Dimock, Janice, Nabozny, Gerald, Goldring, Steven R., McHugh, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274512/
https://www.ncbi.nlm.nih.gov/pubmed/25534583
http://dx.doi.org/10.1038/srep07595