Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion

The cholesterol reducing drugs, statins, exhibit anti-tumor effects against cancer stem cells and various cancer cell lines, exert potent additivity or synergy with existing chemotherapeutics in animal models of cancer and may reduce cancer incidence and cancer related mortality in humans. However,...

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Detalles Bibliográficos
Autores principales: Warita, Katsuhiko, Warita, Tomoko, Beckwitt, Colin H., Schurdak, Mark E., Vazquez, Alexei, Wells, Alan, Oltvai, Zoltán N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274516/
https://www.ncbi.nlm.nih.gov/pubmed/25534349
http://dx.doi.org/10.1038/srep07593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274516/
https://www.ncbi.nlm.nih.gov/pubmed/25534349
http://dx.doi.org/10.1038/srep07593

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