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Role of tautomerism in RNA biochemistry

Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchangeable protons. In DNA, spontaneous formation of minor tautomers has been speculated to contribute to mutagenic mispairings during DNA replication, whereas in RNA, mino...

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Detalles Bibliográficos
Autores principales: Singh, Vipender, Fedeles, Bogdan I., Essigmann, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274630/
https://www.ncbi.nlm.nih.gov/pubmed/25516996
http://dx.doi.org/10.1261/rna.048371.114