Cargando…

Analysis of mRNA recognition by human thymidylate synthase

Expression of hTS (human thymidylate synthase), a key enzyme in thymidine biosynthesis, is regulated on the translational level through a feedback mechanism that is rarely found in eukaryotes. At low substrate concentrations, the ligand-free enzyme binds to its own mRNA and stabilizes a hairpin stru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brunn, Nicholas D., Dibrov, Sergey M., Kao, Melody B., Ghassemian, Majid, Hermann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274661/ https://www.ncbi.nlm.nih.gov/pubmed/25423174 http://dx.doi.org/10.1042/BSR20140137

Ejemplares similares

Translational repression of thymidylate synthase by targeting its mRNA
por: Garg, Divita, et al.
Publicado: (2013)

Interaction between Thymidylate Synthase and Its Cognate mRNA in Zebrafish Embryos
por: Zhang, Yuyan, et al.
Publicado: (2010)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

Quantitative Measurement of Thymidylate Synthase and Dihydropyrimidine Dehydrogenase mRNA Level in Gastric Cancer by Real‐time RT‐PCR
por: Fujiwara, Hisataka, et al.
Publicado: (2002)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Bacterial versus human thymidylate synthase: Kinetics and functionality
por: Islam, Zahidul, et al.
Publicado: (2018)

Dynamic allostery in substrate binding by human thymidylate synthase
por: Bonin, Jeffrey P, et al.
Publicado: (2022)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

A practical approach for assessing chemosensitivity in colorectal cancer cell lines by comparative analysis of cell viability and thymidylate synthase mRNA expression
por: Hwang, Hyun Yong
Publicado: (2012)

Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase
por: Barbour, Karen W., et al.
Publicado: (2013)

Substrate Activation in Flavin-Dependent Thymidylate Synthase
por: Mishanina, Tatiana V., et al.
Publicado: (2014)

Concerted versus Stepwise Mechanism in Thymidylate Synthase
por: Islam, Zahidul, et al.
Publicado: (2014)

Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells
por: Wang, W, et al.
Publicado: (2003)

1-Cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid
por: Dibrov, Sergey, et al.
Publicado: (2009)

(3,4-Dihydroxyoxolan-2-yl)methyl 4-methylbenzenesulfonate
por: Dibrov, Sergey, et al.
Publicado: (2010)

Expression of Thymidylate Synthase in Human Non‐small Cell Lung Cancer
por: Otake, Yosuke, et al.
Publicado: (1999)

Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer
por: Li, Tao, et al.
Publicado: (2020)

Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma
por: YOKOTA, KEISUKE, et al.
Publicado: (2012)

The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1
por: Grünberg, Sebastian, et al.
Publicado: (2023)

Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression
por: Matsuoka, Kazuaki, et al.
Publicado: (2018)

A model for the study of ligand binding to the ribosomal RNA helix h44
por: Dibrov, Sergey M., et al.
Publicado: (2010)

Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment
por: Zhao, Hongyun, et al.
Publicado: (2013)

Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer
por: Kimura, Madoka, et al.
Publicado: (2017)

Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors
por: Srivastava, Vivek, et al.
Publicado: (2010)

Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors
por: Schmitz, John C, et al.
Publicado: (2011)

5-Fluorouracil targets thymidylate synthase in the selective suppression of T(H)17 cell differentiation
por: Wang, Juan, et al.
Publicado: (2016)

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer
por: Kawabata, Shigeru, et al.
Publicado: (2014)

An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes
por: Stern, Adi, et al.
Publicado: (2010)

Significance of thymidylate synthase expression for resistance to pemetrexed in pulmonary adenocarcinoma
por: YANG, MIN, et al.
Publicado: (2014)

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX
por: Basta, Tamara, et al.
Publicado: (2012)

Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC
por: Bukhari, Ali A., et al.
Publicado: (2013)

Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target
por: Choi, Michael, et al.
Publicado: (2016)

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities
por: Maj, Piotr, et al.
Publicado: (2020)

Diagnostic and prognostic value of thymidylate synthase expression in breast cancer
por: Song, Shaoran, et al.
Publicado: (2020)

Expression Levels of Thymidylate Synthase, Thymidylate Phosphorylase and Dihydropyrimidine Dehydrogenase in Head and Neck Squamous Cell Carcinoma: Preliminary Study
por: Aubry, K., et al.
Publicado: (2008)

Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach
por: El-Mesallamy, Hala O., et al.
Publicado: (2018)

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth
por: Pacifico, Salvatore, et al.
Publicado: (2019)

The pemetrexed-containing treatments in the non-small cell lung cancer, is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: a meta-analysis
por: Wang, Lei, et al.
Publicado: (2014)

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing
por: Patel, Kalpesh, et al.
Publicado: (2012)

Early detection of thymidylate synthase resistance in non-small cell lung cancer with FLT-PET imaging
por: Chen, Xiao, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4ksd6oqp2uhrobe2btt52t98sg