B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study

Gene therapy strategies for congenital myopathies may require repeat administration of adeno-associated viral (AAV) vectors due to aspects of the clinical application, such as: (i) administration of doses below therapeutic efficacy in patients enrolled in early phase clinical trials; (ii) progressiv...

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Detalles Bibliográficos
Autores principales: Corti, M, Elder, ME, Falk, DJ, Lawson, L, Smith, BK, Nayak, S, Conlon, TJ, Clément, N, Erger, K, Lavassani, E, Green, MM, Doerfler, PA, Herzog, RW, Byrne, BJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275004/
https://www.ncbi.nlm.nih.gov/pubmed/25541616
http://dx.doi.org/10.1038/mtm.2014.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275004/
https://www.ncbi.nlm.nih.gov/pubmed/25541616
http://dx.doi.org/10.1038/mtm.2014.33

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