The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by γ-secretase, an intramembrane-cleaving protease with multiple substr...

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Detalles Bibliográficos
Autores principales: Mosser, Sebastien, Alattia, Jean-René, Dimitrov, Mitko, Matz, Alexandre, Pascual, Justine, Schneider, Bernard L., Fraering, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275069/
https://www.ncbi.nlm.nih.gov/pubmed/25180020
http://dx.doi.org/10.1093/hmg/ddu449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275069/
https://www.ncbi.nlm.nih.gov/pubmed/25180020
http://dx.doi.org/10.1093/hmg/ddu449

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