Evolution of RNA-Protein Interactions: Non-Specific Binding Led to RNA Splicing Activity of Fungal Mitochondrial Tyrosyl-tRNA Synthetases

The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new function as a group I intron splicing factor by acquiring the ability to bind group I intron RNAs and stabilize their catalytically active RNA structure. Previous studies showed: (i) CYT-18 binds grou...

Descripción completa

Detalles Bibliográficos
Autores principales: Lamech, Lilian T., Mallam, Anna L., Lambowitz, Alan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275181/
https://www.ncbi.nlm.nih.gov/pubmed/25536042
http://dx.doi.org/10.1371/journal.pbio.1002028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275181/
https://www.ncbi.nlm.nih.gov/pubmed/25536042
http://dx.doi.org/10.1371/journal.pbio.1002028

Ejemplares similares