Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome

Sjögren’s syndrome (SS) is an autoimmune disease characterised by breach of self-tolerance towards nuclear antigens resulting in high affinity circulating autoantibodies. Although peripheral B cell disturbances have been described in SS, with predominance of naïve and reduction of memory B cells, th...

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Detalles Bibliográficos
Autores principales: Corsiero, Elisa, Sutcliffe, Nurhan, Pitzalis, Costantino, Bombardieri, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275206/
https://www.ncbi.nlm.nih.gov/pubmed/25535746
http://dx.doi.org/10.1371/journal.pone.0114575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275206/
https://www.ncbi.nlm.nih.gov/pubmed/25535746
http://dx.doi.org/10.1371/journal.pone.0114575

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