Amyloid β-Mediated Zn(2+) Influx into Dentate Granule Cells Transiently Induces a Short-Term Cognitive Deficit

We examined an idea that short-term cognition is transiently affected by a state of confusion in Zn(2+) transport system due to a local increase in amyloid-β (Aβ) concentration. A single injection of Aβ (25 pmol) into the dentate gyrus affected dentate gyrus long-term potentiation (LTP) 1 h after th...

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Detalles Bibliográficos
Autores principales: Takeda, Atsushi, Nakamura, Masatoshi, Fujii, Hiroaki, Uematsu, Chihiro, Minamino, Tatsuya, Adlard, Paul A., Bush, Ashley I., Tamano, Haruna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275254/
https://www.ncbi.nlm.nih.gov/pubmed/25536033
http://dx.doi.org/10.1371/journal.pone.0115923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275254/
https://www.ncbi.nlm.nih.gov/pubmed/25536033
http://dx.doi.org/10.1371/journal.pone.0115923

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