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Amyloid β-Mediated Zn(2+) Influx into Dentate Granule Cells Transiently Induces a Short-Term Cognitive Deficit
We examined an idea that short-term cognition is transiently affected by a state of confusion in Zn(2+) transport system due to a local increase in amyloid-β (Aβ) concentration. A single injection of Aβ (25 pmol) into the dentate gyrus affected dentate gyrus long-term potentiation (LTP) 1 h after th...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275254/ https://www.ncbi.nlm.nih.gov/pubmed/25536033 http://dx.doi.org/10.1371/journal.pone.0115923 |