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Development and Characterization of a Novel Fusion Protein of a Mutated Granulocyte Colony-Stimulating Factor and Human Serum Albumin in Pichia pastoris

The purpose of the present work was to develop a novel, long-acting and potent human serum albumin/granulocyte colony stimulating factor (HSA/G-CSF) therapeutic fusion protein. The novel fusion protein, called HMG, was constructed by genetically fusing mutated human derived G-CSF (mG-CSF) to the C-t...

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Detalles Bibliográficos
Autores principales: Huang, Yan-Shan, Wen, Xiao-Fang, Yang, Zhi-Yu, Wu, Yi-Liang, Lu, You, Zhou, Lin-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275271/
https://www.ncbi.nlm.nih.gov/pubmed/25535738
http://dx.doi.org/10.1371/journal.pone.0115840