Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity

Chimeric antigen receptor (CAR)-redirected cellular therapy is an attractive modality for cancer treatment. We hypothesized that allogeneic CAR-engineered CD45RA-negative T cells can control cancer and infection without the risk of graft-versus-host disease (GVHD). We used CD19(+) MLL-rearranged leu...

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Detalles Bibliográficos
Autores principales: Chan, W K, Suwannasaen, D, Throm, R E, Li, Y, Eldridge, P W, Houston, J, Gray, J T, Pui, C-H, Leung, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275423/
https://www.ncbi.nlm.nih.gov/pubmed/24888271
http://dx.doi.org/10.1038/leu.2014.174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275423/
https://www.ncbi.nlm.nih.gov/pubmed/24888271
http://dx.doi.org/10.1038/leu.2014.174

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