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Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity

Chimeric antigen receptor (CAR)-redirected cellular therapy is an attractive modality for cancer treatment. We hypothesized that allogeneic CAR-engineered CD45RA-negative T cells can control cancer and infection without the risk of graft-versus-host disease (GVHD). We used CD19(+) MLL-rearranged leu...

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Detalles Bibliográficos
Autores principales:	Chan, W K, Suwannasaen, D, Throm, R E, Li, Y, Eldridge, P W, Houston, J, Gray, J T, Pui, C-H, Leung, W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275423/ https://www.ncbi.nlm.nih.gov/pubmed/24888271 http://dx.doi.org/10.1038/leu.2014.174

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