Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesis

Cdx and Hox proteins are homeodomain transcription factors that regulate hematopoiesis. Transcription of the HOX and CDX genes decreases during normal myelopoiesis, but is aberrantly sustained in leukemias with translocation or partial tandem duplication of the MLL1 gene. Cdx4 activates transcriptio...

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Detalles Bibliográficos
Autores principales: Bei, L, Shah, C, Wang, H, Huang, W, Platanias, L C, Eklund, E A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275563/
https://www.ncbi.nlm.nih.gov/pubmed/25531430
http://dx.doi.org/10.1038/oncsis.2014.49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275563/
https://www.ncbi.nlm.nih.gov/pubmed/25531430
http://dx.doi.org/10.1038/oncsis.2014.49

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