In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

Therapeutics based on short interfering RNAs (siRNAs), which act by inhibiting the expression of target transcripts, represent a novel class of potent and highly specific next-generation treatments for human skin diseases. Unfortunately, the intrinsic barrier properties of the skin combined with the...

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Detalles Bibliográficos
Autores principales: Hegde, Vikas, Hickerson, Robyn P., Nainamalai, Sitheswaran, Campbell, Paul A., Smith, Frances J.D., McLean, W.H. Irwin, Leslie Pedrioli, Deena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275573/
https://www.ncbi.nlm.nih.gov/pubmed/25449884
http://dx.doi.org/10.1016/j.jconrel.2014.10.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275573/
https://www.ncbi.nlm.nih.gov/pubmed/25449884
http://dx.doi.org/10.1016/j.jconrel.2014.10.022

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