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In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation
Therapeutics based on short interfering RNAs (siRNAs), which act by inhibiting the expression of target transcripts, represent a novel class of potent and highly specific next-generation treatments for human skin diseases. Unfortunately, the intrinsic barrier properties of the skin combined with the...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science Publishers
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275573/ https://www.ncbi.nlm.nih.gov/pubmed/25449884 http://dx.doi.org/10.1016/j.jconrel.2014.10.022 |